Occasioned by the complicated process of restoring Guarini's masterpiece, the Chapel of the Holy Shroud in Turin, devastated by fire in April 1997, the aim of the workshop is to shed light on the ideological and technical aspects of Guarino Guarini that are hitherto little understood; to understand how Guarini's background as religious and philosopher are expressed in his architecture; and to understand the processes of design and construction through which his concepts are rendered concrete. Participants are a mix of international and local scholars of various aspects of Guarini.
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The 2003 Leonardo: Architecture and Mathematics project was composed of the seminar, during which experts in various fields and from various nationalities assembled to discuss the use of geometry in the architecture of Leonardo as found in his sketchbooks followed by the actual construction of four dome structures based upon Leonardo's system. The seminar and the construction were filmed in order to produce a documentary.

The conference series, Nexus: Relationships Between Architecture and Mathematics, began in 1996 and is now in its sixth edition. Hosted by the Department for the Science of Architecture of the University of Genoa, Nexus 2006 offers a rich program of talks on architecture and mathematics, including a special day dedicated to the history of mechanics.